The Role of Ashwagandha (Withania Som-nifera) on Liver Enzyme, Hepato-oxidative Stress of Induced Hypothyroidism in Male Rabbits

Abstract

This study was designed to evaluate the ameliorative role of Ashwagandha on liver enzyme, lipid profile, glucose and GSH, MDA of induced hypothyroidism in male rabbit. Twenty-four (24) adult male rabbit divided randomly and equally into four groups(C1,C2,T1,T2) C1:control negative group received tap water orally.C2:control positive group received Ashwagandha at dose five hundred 500. mg/kg.B.W. given it oral once daily. T1:Treatment 1 group received propylthiouracil 100 mg/kg.B.W once daily orally. T2:treatment 2 group received both propylthiouracil 100 mg/kg.B.W and Ashwagandha at dose 500 mg/kg.B.W. blood samples were collected by cardiac puncture technique before the experiment started and at the end of the experiment for measuring the following parameters: liver enzyme; Serum ALT (Alanin aminotransferase), AST (Aspartate aminotransferase). lipid profile; Total cholesterol (TC) LiNEAR Spain kit, Triacylglycerol (TAG), High density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL), low density lipoprotein cholesterol (LDL).  Malondialdhyde (MDA), Glutathione (GSH) and glucose. In conclusion, the results of the current study of ashwagandha have hepatoprotrctive effect on the liver and decreased the hepato-oxidative stress.